Lobotomy

A lobotomy is when you really bug the crap out of someone. As Vejos the Token Brute once said in Transylvania 6-5000, "You don't loboto-me, I won't lobot-you". Okay, seriously, a lobotomy is actually a surgical procedure in which a wicked evil doctor cuts up parts of your brain for some sort of bizarre reason. Although the procedure may result in aiding the cause of science, it usually leaves the recipient a babbling idiot.

American Horror Story

 * American Horror Story: I Am Anne Frank (Part 2)

In film

 * Brain Dead